One day after it was revealed that a new highly-mutated Omicron subvariant had arrived in California, Los Angeles Public Health Director Barbara Ferrer announced the first case had been unidentified in Los Angeles.
30.06.2022 - 12:57 / dailyrecord.co.uk
It is possible to reverse a key process that allows pancreatic cancer cells to grow and spread around the body, scientists have found.
Researchers suggest the findings could ultimately pave the way for new treatments of the disease.
The study shows that a protein called GREM1 is key to controlling the type of cells found in pancreatic cancer.
According to the researchers, manipulating the levels of this protein can both fuel and reverse the ability of these cells to become more aggressive.
Professor Axel Behrens, leader of the Cancer Stem Cell Team at The Institute of Cancer Research, London (ICR) was senior author of the study.
He said: “This is an important and fundamental discovery that opens up a new avenue for uncovering treatments for pancreatic cancer.
“We have shown that it is possible to reverse cell fate in pancreatic cancer in the lab – turning back the clock on aggressive tumours and switching them to a state that makes them easier to treat.
“By better understanding what drives the aggressive spread of pancreatic cancer, we hope to now exploit this knowledge and identify ways to make pancreatic cancer less aggressive, and more treatable.”
Pancreatic cancer has the lowest survival rates of common cancers.
Less than 7% of people will survive for five years or more.
In the UK, more than 10,000 people are diagnosed with pancreatic cancer each year, and more than 9,000 will die from it.
The ICR researchers studied pancreatic cancer with the gene that makes the GREM1 protein switched off in mice, and in pancreatic ‘mini-tumours’, which are also known as organoids.
They found that switching off the GREM1 caused the tumour cells to rapidly change shape and develop new properties that help them invade new tissues and migrate
One day after it was revealed that a new highly-mutated Omicron subvariant had arrived in California, Los Angeles Public Health Director Barbara Ferrer announced the first case had been unidentified in Los Angeles.
Showtime’s Your Honor will end after its upcoming season, series star Bryan Cranston said today in an interview on Dax Shepard’s Armchair Expert podcast. Filming on Season 2 has just started, with Joey Hartstone, who was a writer on Season 1, as new showrunner, Deadline has learned. Additionally, I hear Keith Machekanyanga, who recurred heavily as Lil Mo in the first installment, has been promoted to series regular for Season 2.
The 1975‘s frontman Matty Healy has rejoined Reddit and shared details about the band’s new album with fans.Last week, the band revealed the title and tracklist for fifth album ‘Being Funny In A Foreign Language’, which will be previewed this Friday (July 7) with first single ‘Part Of The Band’.A sax-flecked snippet of the track was shared on Instagram by Matty Healy last week, and lyrics to ‘Part Of The Band’ appeared on billboards. “She was part of the airforce / I was part of the band,” the song begins, with other lyrics including: “Am I ironically woke? The butt of my joke? Or I am just some post-coke, average, skinny bloke calling his ego imagination?”Commenting on a Reddit post about the band’s new album, Healy told fans: “Hey guys I’ve just started doing interviews where I explain the record and it’s context.”He went on to explain that ‘New York’, a song believed to be a new 1975 track that he performed live in Los Angeles while supporting Phoebe Bridgers last year, is actually by Dirty Hit labelmate Benjamin Francis Leftwich.“I love the song and it didn’t have a bridge.
a new music venue set to open in London this autumn, has announced its first wave of shows for 2022 – see all the details below.The performance space will form part of Outernet London, “a billion-pound immersive media, music and culture district” that will be located on the corner of Oxford Street and Charing Cross Road.HERE at Outernet, which is said to be the largest live events venue to be built in the centre of London since the 1940s, will sit beneath The Now Building, which is described as “the most advanced experiential public space in the world” that’ll feature 23,000 sq. ft.
Tessa Thompson must have a great relationship with the staff at her NYC hotel!
Naman Ramachandran A wealth of film and TV titles are available at launch on streamer Studiocanal Presents, which is now available as an Amazon Prime Video channel in the U.K.Some 300 films and series from Studiocanal’s catalogue are available at launch, including Francis Ford Coppola’s “Apocalypse Now: Final Cut” in 4K; Brian Helgeland’s “Legend”; Joel and Ethan Coen’s “Inside Llewyn Davis”; a digitally restored version of Carol Reed’s “The Third Man”; Lynne Ramsay’s “You Were Never Really Here,” zombie horror “Train to Busan” and Céline Sciamma’s “Girlhood.”Also available are Nicolas Roeg’s “The Man Who Fell To Earth” and Sidney Lumet’s “Murder on the Orient Express,” award-winners “Manchester by the Sea” and “Room,” seminal titles like Luis Buñuel’s “Belle de Jour” and Jean-Luc Godard’s “Breathless” and modern British classics “Submarine” and “Four Lions.” Other recent additions include Sharon Stone classic “Basic Instinct” and John Carpenter’s “Escape From New York.” Studiocanal Presents also offers TV series showcasing the best of Studiocanal and Canal+’s own TV productions, including “Hannibal,” “Spiral” and “All the Way Up,” which broke streaming records upon its launch on Canal+ in France.A variety of new titles will launch on the channel every month, many of which can’t be streamed anywhere else in the U.K. New titles arriving include “Possessions,” “Animal Kingdom” and “The Guard.” After a seven-day free trial the service costs £4.99 ($6) a month.
Bicep have released a new version of fan-favourite ‘Meli (I)’ called ‘Meli (II)’ and have unveiled details of a huge new London show.The new single is a 4×4 live-reworking of the beatless “Meli (I)” from their ‘Isles Deluxe’ release last year.Speaking about the re-working of the original track, the band said: “’Meli (I)’ was a beatless track on ‘Isles Deluxe’. Truth be told we just couldn’t get a drum version right in the studio throughout the pandemic, there were many failed demo versions whilst we were working on ‘Isles’, it just never felt like it worked.“We always knew there was room for this version though, hence naming the original ‘Meli (I)’. ‘Meli (II)’ was formed slowly on the road.
Spacey Unmasked is set to take a forensic look into the actor’s career, from his childhood, success on Broadway and star status, to his fall from grace following multiple allegations of grooming, sexual harassment and abuse.The two-part series comes from director Kira Phillips, and will air after the outcomes of two court cases against Spacey – a civil case brought by actor Anthony Rapp in New York set to be heard in October, and UK criminal charges relating to allegations by three men.“Kevin Spacey is one of the most highly honoured and admired actors of our age,” said executive producer Dorothy Byrne. “His brilliance has won him two Oscars and multiple other awards.“Critically acclaimed on both sides of the Atlantic for his film work, he led the Old Vic for 11 years of remarkable success, becoming one of the most important figures in London’s cultural life, a friend to some of its leading figures, making regular appearance in society columns.“These films will follow the unfolding story of the allegations of abuse against him and the resulting court cases.”Spacey appeared in a UK court earlier this month after being charged with four counts of sexual assault relating to alleged offences in London and Gloucestershire between 2005 and 2013.
Following its acclaimed run at The Bridge Theatre in London, David Hare’s Straight Line Crazy starring Ralph Fiennes as New York powerbroker Robert Moses will make its Big Apple Off Broadway debut this fall at The Shed. Directed by Nicholas Hytner and Jamie Armitage, the play will run Oct. 18 to Dec. 18.
Scotland's tax system is not fit for the future and needs to be completely redesigned, according to a new report from a think tank.
cancer doesn't usually cause symptoms in the early stages, but "as the cancer grows it can start to cause symptoms". The charity advises: "Symptoms of pancreatic cancer can be vague. They can be caused by other conditions, but it's important to get them checked by a doctor.
Mura Masa has released a brand new single, ‘hollaback bitch’ – you can check it out below.The Guernsey musician’s latest track – which features Shygirl and Channel Tres – is the latest preview of his upcoming third album, ‘demon time’, which is set to be released on September 16 via Polydor Records.The follow-up to 2020’s ‘R.Y.C.’ will also feature previously released tracks, ‘blessing me’ (with Pa Salieu and Skilliben), ‘2gether’ and ‘bbycakes’ (with Lil Uzi Vert, PinkPantheress and Shygirl).Combining elements of house, early 2000s R&B and vogue culture, as well as a slick rap verse from LA-based artist Channel Tres, you can check out ‘hollaback bitch’ below:Besides releasing the fresh club single, Mura Masa has also revealed the tracklist for ‘demon time’.In addition to the aforementioned singles, the album will also feature fresh cuts like ‘up all week’ featuring Slowthai, ‘slomo’ with Tohji and Midas The Jagaban and ‘blush’ with Leyla.Check out the tracklist for ‘demon time’ below:Mura Masa is currently in the midst of a summer tour that will include performances at All Points East and this weekend’s Glastonbury.
Good 4 her! Olivia Rodrigo is seeing Zack Bia, a source tells Us Weekly.
Sony Music last week told the high court in London that a dispute over the rights in the Jimi Hendrix Experience recordings should be heard in the New York courts, because the legal battle centres on agreements signed in the 1970s in the US. And a separate lawsuit in relation to this dispute has already been filed with the courts in New York.The dispute is between Sony Music and the Jimi Hendrix estate on one side, and UK-based companies representing the estates of the other two members of the Jimi Hendrix Experience band – Noel Redding and Mitch Mitchell – on the other.
cancer - a form of cancer with slim odds of survival. Little was said about Ben Gazzara's death but his attorney revealed to various media outlets that the 81-year-old died from the disease in Manhattan hospital. Pancreatic cancer starts in the pancreas - an organ that produces enzymes for breaking down food as well as the hormones such as insulin, which help to regulate blood sugar.