“Scream VI” is currently in theaters, after opening to the biggest first weekend in the franchise’s history.Set in New York City and following the survivors of 2022’s “Scream” (including Melissa Barrera and Jenna Ortega) as they encounter yet another crazed madman (or madmen) in a Ghostface mask. But what is this killer’s connection to earlier murders and what do previous survivors Gale Weathers (Courtney Cox) and Kirby Reed (Hayden Panettiere) have to do with this mystery?TheWrap talked with directors Matt Bettinelli-Olpin and Tyler Gillett about your burning questions, including going in depth on the opening sequence, the absence of Neve Campbell (over a salary dispute) and how heavily “Scream 2” loomed over this movie.Major spoilers for “Scream 6” follow; if you haven’t watched the movie yet, turn back now.Let’s start at the beginning with the cold open. Can you take me through the process of developing that sequence?Tyler Gillett: What is surprising and entertaining in the viewing of it, that was the experience we had reading it.