*SPOILER ALERT* You've been warned! Grey's Anatomy loyalists were in for a rude awakening when they found out what the long-running series' makers had in mind while giving the beloved OG 5 character Alex Karev the 'perfect' send-off! It was revealed through a voiceover cameo by Justin Chambers that Alex had left everything, including now ex-wife Jo (Camilla Luddington) to reunite with Izzie Stevens (Katherine Heigl) and their surprise twins Eli and Alexis.