Former jurors weighing in! Big Brother alums Claire Rehfuss and Derek Xiao exclusively gave Us Weekly their thoughts on season 24 as the finale looms near.
02.09.2022 - 13:15 / dailyrecord.co.uk
Recent research has uncovered new potential treatments for the most severe form of skin cancer.
Melanoma is the fifth most common cancer in the UK, with 16,700 people diagnosed with the condition in the UK each year, according to Cancer Research UK.
The charity research group adds that the number of people diagnosed with melanoma has increased over the last few decades.
Right now, treatment will depend on the stage and depth of a person's melanoma, and can include surgery, immunotherapy, radiotherapy and chemotherapy.
However, a new study by Sanford Burnham Prebys in California has revealed that inhibiting a key metabolic enzyme could selectively kill melanoma cells and stop tumour growth, reports Wales Online.
The researchers, whose findings were published in the journal Nature Cell Biology, say their findings could lead to a new class of drugs to selectively treat melanoma.
Study leader Professor Ze’ev Ronai, director of the Cancer Centre at Sanford Burnham Prebys, said: “We found that melanoma is addicted to an enzyme called GCDH.
"If we inhibit the enzyme, it leads to changes in a key protein, called NRF2, which acquires its ability to suppress cancer.
"Now, our goal is to find a drug, or drugs, that limit GCDH activity, potentially new therapeutics for melanoma."
Because tumours grow rapidly and require lots of nutrition, scientists have been investigating ways to starve cancer cells. However, as promising as the approach may be, the results have been less than stellar. Denied one food source, cancers invariably find others.
Prof Ronai explained that GCDH, which stands for Glutaryl-CoA Dehydrogenase, plays a "significant" role in metabolising lysine and tryptophan, amino acids that are essential for human health.
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Former jurors weighing in! Big Brother alums Claire Rehfuss and Derek Xiao exclusively gave Us Weekly their thoughts on season 24 as the finale looms near.
New Order and Pet Shop Boys kicked off their joint North American tour over the weekend – see footage, pictures and the setlists from their opening night below.The British synthpop titans’ tour got underway at Toronto’s Budweiser Stage on Saturday (September 17) following delays due to the COVID pandemic.The Unity Tour’s revised dates include guest DJ Paul Oakenfold and take in an additional date at Brooklyn’s Barclays Center in New York. Head here for any remaining tickets.New Order opened their set on Saturday with ‘Regret’ and wrapped with a cover of Joy Division‘s ‘Love Will Tear Us Apart’.Pet Shop Boys, meanwhile, opened with ‘Surburbia’ before closing with ‘Being Boring’.
Florence Pugh and Chris Pine, were noticeably absent from the New York premiere. The A-list Hollywood actors appeared to skip the event after they were dragged into the ongoing drama that surrounds the psychological thriller. Pugh is said to be locked in a feud with director Olivia Wilde after reportedly disapproving of the way she began a relationship with leading man Harry Styles during filming and while still believed to be in a relationship with ex-fiancé Jason Sudeikis.
"Don’t Worry Darling" stars Chris Pine and Florence Pugh were both absent from the film’s event in New York City. The Hollywood actors explained their absence, stating that they are both working on other projects, in a video message ahead of the film’s screening Monday. "Even though I'm working halfway around the world," Pugh said. "…and I'm all the way in Los Angeles in production myself," Pine added in their joint message.
Feline energy! Kim Kardashian took her love of pantaboots to a new level, stepping out in a tiger print pair while visiting New York.
Moment of frustration. Tom Brady is apologizing for an emotional outburst that took place during the recent game between the Tampa Bay Buccaneers and the New Orleans Saints.
SEVENTEEN’s Jun will be dropping a brand-new solo single titled ‘Limbo’ later this week.On September 19 at Noon KST, Jun (real name Wen Junhui) announced the upcoming release via SEVENTEEN’s official Twitter account with a mysterious teaser image. The ‘Limbo’ teaser features the singer showcasing his back, while a gloved hand rests atop his shoulder.‘Limbo’ is due out on September 23 at 1:00pm KST.
Katie Reul editor As the East Coast’s largest pop culture convention, the annual New York Comic Con (NYCC) is a space for comic, film and TV enthusiasts alike to find community in fandoms — all while in the city that never sleeps. This year, the convention returns to the Jacob K. Javits Convention Center from Oct. 6-9 with a stacked lineup of panels, exhibitions and exclusive VIP experiences. Similar to last year’s hybrid format, attendees have the choice of purchasing tickets at $22.75 a piece for digital access to the event’s in-person programming. Panels in major convention halls will be streamed over live video, while audio streams will be available for smaller rooms.
Father John Misty has covered Stevie Wonder‘s ‘I Believe (When I Fall in Love It Will Be Forever)’ as part of a new live EP.‘Live At Electric Lady’ was recorded at the iconic Electric Lady Studios in Greenwich Village, New York City back in May. Comprising six tracks, the special collection contains live versions of five songs from FJM’s latest album ‘Chloë And The Next 20th Century’.Closing the EP is Father John Misty’s take on Wonder’s 1972 number ‘I Believe…’. You can listen to ‘Live At Electric Lady’ on Spotify below.Announcing the project on social media, FJM (real name Josh Tillman) shared a series of behind-the-scenes shots of himself and his accompanying string section recording at NYC’s Electric Lady.
It was five years ago when Pan-n-Ice landed in Manchester, taking a spot within Selfridges’ food Hall at The Trafford Centre. And today, they launched a second parlour at Manchester Arndale, keeping queues of hungry shoppers happy with their unique ice cream and frozen yoghurt rolls.
What’s going on with Gisele Bündchen and Tom Brady?? It’s a question a lot of fans of the couple are asking right now, as rumors of their relationship troubles are spiraling out of control.
Angel Olsen has recruited Sturgill Simpson for a new version of her recent single ‘Big Time’ – check it out below.‘Big Time’ appears on Olsen’s new album of the same name, which was released back in June.“It’s crazy to write a song and then watch someone else you really admire sing your words; kinda turns the whole thing on its head.” Olsen said of the new version in a statement.“I loved the song already, but hearing Sturgill’s take on ‘Big Time’ made me smile ear to ear, he made it come alive on a different level.”Listen to Olsen and Simpson’s ‘Big Time’ collaboration below.After the release of her ‘Big Time’ album, Olsen has spent the summer touring the United States with Sharon Van Etten and Julien Baker as part of ‘The Wild Hearts Tour’.Last month, the tour wrapped up with two shows in New York’s Central Park and saw Baker join Olsen and Van Etten to perform the latter pair’s joint single ‘Like I Used To’.Olsen and Van Etten had performed the song together across the entirety of the North American tour – a triple-headliner stint that spanned 20 shows over the past month – appearing in the encore during either of their individual sets. They played it with Baker as part of Van Etten’s set in the park – it was the first to see Baker join in.Olsen will head out on a UK and Ireland tour in support of ‘Big Time’ in October.
plays a gay British cop named Tom during the 1950s, and his secret lover Patrick (David Dawson) is a museum curator and artist. When Tom’s girlfriend Marion (Emma Corrin of “The Crown”) notices a drawing of Tom by Patrick on the wall, she expresses her shock that her so-so beau was the chosen subject.Tom shoots back: “Patrick says ordinary people are the best faces to draw!”The Toronto International Film Festival crowd at the Princess of Wales Theatre roared with laughter at the line, knowing full well that Styles, who was in attendance, has graced covers of Vogue, GQ and Rolling Stone and regularly has headlines written about him such as “Harry Styles Is ‘Uncomfortable’ as a Sex Symbol.”This summer, Styles has been everywhere.
Kourtney Kardashian and Travis Barker have mastered the art of coordinated couple style. The lovebirds attended the Tommy Hilfiger spring 2023 show during New York Fashion Week in looks that had Us doing a double take.
Meghan Markle and Spotify are hitting pause on upcoming episodes of, followingthe death of Queen Elizabeth, ET has confirmed.The podcast premiered last month and debuted on the top charts in the United States, United Kingdom, Canada, Ireland, Australia and New Zealand. releases new episodes every Tuesday. So far, the Duchess of Sussex has had conversations with Serena Williams, Mariah Carey and Mindy Kaling. Additional guests scheduled to appear are Constance Wu, Issa Rae, Lisa Ling, Margaret Cho and Ziwe. Markle is currently by her husband’s side in the U.K.
Rebecca Rubin Film and Media Reporter On the stage at New York City’s Madison Square Garden, Harry Styles is a bonafide rock star, brimming with swagger and self confidence. But Styles, the actor, was more soft spoken while accepting an acting award at the Toronto International Film Festival. Styles was a man of few words as he, along with the cast of “My Policeman,” received the ensemble award at the festival’s Tribute Awards on Sunday. “Thank you so much to everyone here on behalf of all of us for this wonderful, wonderful award,” said Styles, who stars in the romance drama as a closeted police officer. “We all loved working on this film so much. And we hope you enjoy it.”
Gene Maddaus Senior Media Writer Director Paul Haggis is scheduled to face a civil trial in New York next month on an accusation that he raped publicist Haleigh Breest after a film premiere in 2013. The trial will come nearly five years after the suit was filed, and just a couple of months after an Italian court dismissed a similar accusation against the director. Breest’s lawyers are now seeking information about the Italian case, which they may seek to introduce at the New York trial. In a motion filed on Tuesday, they asked Judge Sabrina Kraus to order Haggis’ lawyers to turn over records related to the case.
Black Country, New Road have covered Billie Eilish‘s song ‘Happier Than Ever’ during a recent show on their current US tour.The rock band performed the track — the title track from Eilish’s 2021 album — at New York City’s Bowery Ballroom yesterday (September 5), adding new elements to the part-sombre, part-thunderous rendition.BCNR violinist Georgia Ellery introduces classical strings to the lullaby-like intro, before drummer Charlie Wayne belts out the song’s punk-pop latter half, with vocal assists from the rest of the band as they mosh on stage. The cover elsewhere enlists keys from May Kershaw and saxophone riffs courtesy of Lewis Evans.
Sex Pistols’ Glen Matlock is to appear on Blondie‘s new album.The bassist previously stepped in for Leigh Foxx on Blondie’s April 2022 UK and US tour after Foxx suffered a back injury. Now, the musician has been announced to play bass on the band’s follow-up to 2017’s ‘Pollinator’ while Foxx recuperates.Speaking to Classic Pop magazine, guitarist Chris Stein said: “Glen has just been great.
BBC Three is to adapt Holly Jackson’s New York Times bestselling teen crime thriller A Good Girl’s Guide To Murder from Amazon Prime Video’s The Pursuit of Love producer Moonage Pictures.