A Manchester restaurant that has only been open a matter of months has shot into a prestigious list of the very best restaurants in the UK. Higher Ground has placed at 51 in the National Restaurant Awards Top 100 announced last night.
01.06.2023 - 18:13 / dailyrecord.co.uk
A new study has found that a drug used to treat Parkinson's disease is able to safely slow the progression of an incurable form of motor neurone disease for over six months.
Clinical trials showed that ropinirole delays the symptoms of Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. It claimed the life of cosmologist Stephen Hawking.
ALS, which does not have a cure, causes people to gradually lose control of their muscles. At the moment, treatments focus on reducing the symptoms and providing supportive care.
But now Japanese scientists have shown that ropinirole, used to treat the symptoms of Parkinson's disease and restless legs syndrome, is safe to use in ALS patients and delayed disease progression by an average of 27.9 weeks.
Some patients were more responsive to ropinirole treatment than others, according to the findings published in the journal Cell Stem Cell.
Senior author Professor Hideyuki Okano, of the Keio University School of Medicine in Tokyo, said: "ALS is totally incurable, and it's a very difficult disease to treat.
"We previously identified ropinirole as a potential anti-ALS drug in vitro, and with this trial, we have shown that it is safe to use in ALS patients and that it potentially has some therapeutic effect.
"But to confirm its effectiveness we need more studies, and we are now planning a phase three trial for the near future."
To test ropinirole's safety and effectiveness in patients with sporadic ALS, the team recruited 20 patients receiving care at Keio University Hospital.
None of the patients carried genes predisposing to the disease, and, on average, they had been living with ALS for 20 months.
The patients and doctors did not know which patients were receiving ropinirole and
A Manchester restaurant that has only been open a matter of months has shot into a prestigious list of the very best restaurants in the UK. Higher Ground has placed at 51 in the National Restaurant Awards Top 100 announced last night.
This Morning fans have been left 'uncomfortable' over Ruth Langsford and Holly Willoughby's latest exchange, after an 'awkward' segment on the show today. Ruth, 63, who's husband Eamonn Holmes, 62, has been publicly bashing Holly, 42, and her former co-host Phillip Schofield, 61, was anchoring Monday's Loose Women, which runs straight after This Morning. As normal, This Morning cut to Loose Women, where viewers find out what the Loose Women panel will be talking about on that day's show.
Gavin Newsom didn’t back down from Sean Hannity’s fiery questioning about the homeless crisis in California – including its relative size compared with de facto rival Florida – saying “we own” the numbers and blaming the cost of housing and “localism.”“The state has not made progress in the last two decades as it relates to homeless,” the California governor said flatly at the top of an excerpt provided by Fox News, which you can watch below. The entire interview, Newsom’s first with the conservative cable news network in over a decade, was scheduled to air Monday night at 9 p.m.
Eric André dropped a whopping 40 pounds and trimmed down to under nine percent body fat for season 6 of his Adult Swim show. The good news? He liked what he saw in the mirror. The bad news? It was irritating for a devotee of French fries.
Eric André dropped a whopping 40 pounds and trimmed down to under nine percent body fat for season 6 of his Adult Swim show. The good news? He liked what he saw in the mirror. The bad news? It was irritating for a devotee of French fries. The 40-year-old comedian opened up to about the rigorous process he put his body through while filming the latest season of.
Lainey Wilson revealed she has been cozying up next to Devlin "Duck" Hodges for more than two years. After the country star and former NFL player stepped out together on the 2023 ACM Awards red carpet for the first time in May, Wilson, 31, admitted they have been dating for quite some time. "He's been around for a while. I just decided to make him wait for two and a half years," she laughed on "The Bobby Bones Show." The "Yellowstone" star added that Hodges, 27, is "a good dude" and continued to explain why they decided to wait to publicly debut their relationship. "He knows what it's like chasing a dream because he's done that for himself," Wilson said.
Lainey Wilson just made her red carpet debut with boyfriend, Delvin “Duck” Hodges, last month – but the truth is that they’ve been dating for over two years!
A mum-to-be has spoken of her horror after discovering her husband was having an affair with her best friend while she was pregnant.
AO is to create over 250 jobs at its Bolton headquarters and revealed successful applicants could receive a 20% pay rise within a year.
Not a fan. Arnold Schwarzenegger revealed that his time as the governor of California almost never came to be because of his now-ex-wife, Maria Shriver.
From Terminator to Governator! Arnold Schwarzenegger played many roles throughout his impressive career.
Greater Manchester's previous deputy mayor will stay in a paid position for another six months as her employment is extended until the end of the year. Baroness Beverley Hughes, who formally resigned in January from the role which oversees police, crime, the criminal justice system and the fire service, has been working part time in a newly-created post since she stepped down.
News spread this week that Al Pacino, 82, is having a baby with Noor Alfallah, 29, any day now….but sources are saying there is more to the story.
Yvie Oddly is speaking out about the producers of RuPaul’s Drag Race.
The Scottish Government has been urged to help a mum and her son to find lifesaving treatment for Lyme disease.
CNN reported, with Universal Music Group likely to snatch up anthems like “We Are the Champions,” “We Will Rock You” and “Another One Bites the Dust” from Disney Music Group in a deal that “could surpass $1 billion.”A spokesperson for the Disney Music Group told CNN the company has no plans to sell the catalog. Disney did not immediately respond to a request for comment Tuesday morning.Disney reportedly paid $10 million for the distribution rights to the band’s catalog in 1991.Should “Bohemian Rhapsody,” “Crazy Little Thing Called Love,” and the rest of the Rock-and-Roll Hall of Fame band’s songs pull in the reported $1 billion, it would be the largest sale of a music catalog so far, knocking Bruce Springsteen from the top of the heap.
Asda is to buy the majority of EG Group's UK and Ireland operations in a deal worth over £2bn.
A mum whose son waited two years for treatment is calling on the Scottish Government to do more for people with Down Syndrome.
Stars posed up a storm on the amfAR Cannes gala red carpet on Thursday, but Leonardo DiCaprio, as per usual, chose to keep his entrance on the down low.
Ricky Gervais and Sharon Horgan’s agent has said creatives should “be careful what they wish for” when considering whether to launch production companies.